In this work the analysis of observations of patients with polytrauma of older age groups (95 patients) was performed, the control group consisted of patients with polytrauma in age from 20 to 40 years (55 patients). The aim of the study was to define a set of laboratory parameters and the degree of deviation from the norm, the changes of which most closely correlated with the dynamics of the patients' condition, allowing objectively justify the choice of treatment strategy on the stages of DCS. Among them are the blood count (RBC, HGB), total blood protein, blood albumin and abnormalities in blood coagulation system. Objectivization of assessing criteria of condition permitted to reduce the mortality rate by 9.6%.

The expectorant activity research of infusions and water-soluble polysaccharide complexes of Salvia genus plants was carried out on the model of studying of motor function of the ciliated epithelium of frog esophagus. Experimentally, it was found that the investigated phytopreparations have an expectorant activity to some extent. The most effective ones are the infusion (an increase of motor activity is 41,26 ± 2,14%) and a water-soluble polysaccharide complex of Salvia horminum L. (an increase of motor activity is 45,38 ± 4,24%), which exceed Salvia's officinalis effect in respect of the strength of pharmacological activity. The rest are close by the action of an expectorant activity to officinal species Salvia officinalis L.

The study shows some changes in prooxidant-antioxidant systems both in the bile and blood in patients with obstructive jaundice. Among the indicators of antioxidant defense the greatest increase in activity was observed in catalase (by 4,5-5,1 times) and superoxide dismutase (by 13,1-16,3 times) in the bile in the development of cholangitis. Significant violations have also been revealed at the local and systemic level in the low-molecular activity of the antioxidant system, which were compensatory in choledocholithiasis and were manifested by increasing plasma (57,9%) and bile (8,2%) antioxidant activity. In addition, intensification of free radical oxidation has been marked which was revealed in the blood plasma in malignancy of biliopankreatoduodenal zone (3,0 times), reflecting regulatory changes at the system level. A more frequent use of bile for diagnosis also allows its more adequate monitoring the status of patients with obstructive jaundice due to the comprehensive analysis of local prooxidant-antioxidant system indicators.

Early diagnosis of aortic stenosis may begin with the identification of left ventricular hypertrophy by two-dimensional Doppler echocardiography. For aortic stenosis characterized by concentric left ventricular remodeling, when the index for normal left ventricular mass index increased relative wall thickness. We analyzed 48 cases of aortic stenosis. Patients were divided into two matched groups: the first group - patients with critical aortic stenosis, the second - with easy aortic stenosis. Patients of the first group prevailed concentric left ventricular hypertrophy in patients of the second group of normal left ventricular geometry. And in one and in the other group almost half of the patients had concentric remodeling of the left ventricle. A moderate positive correlation maximum gradient on the aorta and the thickness of the interventricular septum and the left part of it.

The results showed a highly significant increase in blood levels of nitrites background of decreasing the total amount of nitrites/nitrates levels in the blood of patients with bronchial asthma and chronic obstructive pulmonary disease, indicating a violation of the functional activity of vascular endothelium and nitric oxide synthesis during acute diseases.

Three types of maxillary dental arches were identified: vestibular dental arch, lingual alveolar arch, and dentoalveolar arch. The vestibular dental arch is to be reproduced through connecting the dots at the most prominent part in the vestibular contour of the teeth crowns' occlusal surface, which constitute the dental arch. The alveolar lingual arch was formed through connecting the dots located at the lingual surface of the dental arch in the interdental spaces. The way to shape the dentoalveolar arch implied joining the dots of the lingual alveolar arch at the anterior part (between the distal surfaces of maxillary canines) and the middle of the distal surface of the premolars and molars' occlusal contour. The frontal distal diagonal of the dental arches was found to be the key factor that determines the match between the teeth size and the dental arches.

The rheoperiodontography method was employed to estimate both qualitative and quantitative parameters in children and adolescents (aged 12-15) with physiological occlusion and dentoalveolar anomalies in order to analyze their periodontium hemodynamics. Patients with hypoplasia of the jaws and teeth overcrowding reveal change in the vascular reactivity of periodontium along with an advanced activity of the mechanisms responsible for the vascular tone rise and decreased elasticity of the vascular wall. These are indicative of the pre-clinical signs of periodontal disease leading to persistent vasoconstriction and microcirculatory disorders.

Studied functional performance of the lower esophageal sphincter in 32 patients with decompensated scar-ulcer duodenal stenosis. Shows the value of stenosis of the duodenum in the formation of a hernia hiatal and reflux esophagitis, and the degree of failure of the esophageal-gastric junction, depending on the degree of stenosis of the duodenum.

The results of correction of immune status in patients with pyo-necrotic forms of diabetic foot are presented. It is established that the clinical signs of secondary immune deficiency in patients with pyo-necrotic forms of diabetic foot are accompanied by changes in laboratory immunological parameters: the presence of relative and absolute lymphopenia; reduction in the relative and absolute T-lymphocyte numbers, and of subpopulations of CD4 lymphocytes, as well as levels of phagocytosis. The data presented indicates that inclusion of immunomodulators into the treatment program in patients with pyo-necrotic forms of diabetic foot led to a reduction in treatment time, complications, and to positive changes in the parameters characterizing the state of the immune system.

A study of the psychoemotional status of patients with burning mouth syndrome identified anxiety, fear, confusion, tension, emotional lability, cancerophobia varying degrees of severity. The authors have proved the efficiency of correction of psychoemotional status of the patients with burning mouth syndrome with the use of tenoten.

This article describes how to misconceptions, myths and stereotypes in society for mental patients, lead to discrimination against them, impede their social adaptation and reduce the quality of life. Often such a stigma turns into the second disease that can be for patients heavier than itself a mental disorder. Describes how stigma exposed except for their sick relatives, doctors, psychiatrists and mental health services. Describes the origins of stigmatization and possible ways to mitigate.

This article describes how the rapid development of modern psychotherapy led to a wide variety of areas, and schools, making it difficult to even its single definition. In domestic psychotherapy are two different areas: clinical and psychological therapy, which differ on the project (patients and clients) and their means, which makes their differences with respect to the diagnosis. In psychological therapy services primarily mentally healthy individuals (clients) with personal and situational problems, which are reflected in the symbolic form of symptoms, psychiatric diagnosis and, therefore, is of secondary importance. While clinical psychotherapy busy treating people with mental disorders, for which the identification of symptoms and psychiatric diagnosis is essential. The expediency of psychiatric diagnosis prior to psychological therapy. The expediency of adequate combined use of psychopharmacological and psychological tools in clinical psychotherapy. The analysis of the differences between the concepts of the phenomenon and psychopathological symptoms. Describes the idea of the systemic nature of psychopathological symptoms and justifying the importance of symptomatic therapy.

The influence of the chronic psycho-emotional stress (CPES) on the formation of the endothelial dysfunction (ED), the processes of vascular remodeling and the indicators of cerebral hemodynamics was explored. As a model of the effect of CPES 160 railroad engineers were examined. As a control, 100 healthy volunteers were examined. It is shown that the effect of CPES accompanies increasing production of the central (adrenocorticotropic) and the peripheral (cortisol, corticotropin) stress hormones. The effect of stress system has the serial reaction: periods of activation, resistance and allostasis. In the early stages of the stress impact the formation of ED take place. It is characterized by decreased secretion of the vasodilator NO and increasing production of the vasoconstrictor endothelin-1. ED stimulates vascular remodeling. In the large vessels of elastic type remodeling leads to thickening of the intima-media complex. In the vessels of muscular type is an increase in vascular tone, increased peripheral resistance, which is accompanied by a decrease in blood flow velocity.

As a result of the research it was revealed that pregnant women with bacterial vaginosis change indicators feto-placental complex, leading to various complications of pregnancy. The use of abnormal Doppler waveforms and ultrasound allows early to diagnose placental insufficiency.

After surgical treatment of chronic extrasphincteric fistulas 5-30% develop recurrence in 15-80% - anal incontinence. To improve the results of a new method of surgical treatment - translocational proctoplasty comprising excision of fistulous and eliminate the internal opening by moving the mucosa of the anal canal. All participants are divided into two groups using a new method (basic, n=36) and a ligation method (control, n=45). Day bed in the main group 13,9±1,5 days in the control - 18,6±1,7 days (p <0,05). The results of postoperative sphincterometry in the main group - in the normal range, the control -Significant decreased tone and minimize. Recurrence of the disease in the study group was not in control -2 (4,4%) (p <0,05). The proposed method is more effective than the a ligation method.

By 89 patients with angina pectoris of the third functional class (FC), a regulatory-adoptive status by parameters of cardio-respiratory synchronism was determined. The sick were divided in four groups by the presence of a certain pathology. In the first group 29 patients were included with the tensional angina pectoris without a pathology. The second group (20 patients) consisted of patients,whose angina pectoris went together with hypertonic disease, in the third-the patient with the tensional angina pectoris and the second type diabetes (20 patients),in the fourth-the patients with the tensional angina pectoris combined with hypertonic disease and the second type diabetes (20 patients). By the patients in the first group the regulatory-adaptive status was the highest. With the following diseases (hypertonic diseases, diabetes and their combinations) the status was getting lower. So, the following pathology by the patient with the tensional angina pectoris lessens their regulatory-adaptive status.

We conducted a statistical analysis of the data, which are included in the regulatory and adaptive capabilities (RAC) estimation algorithm, to obtain the forecasting of maximum boundary (Max.B.) of synchronization range of cardiac and respiratory rhythms, in order to minimize the definition time of RAC of the human body by the method of the cardiorespiratory synchronism (CRS). The following factors have been examined as the basis of the Max.B. forecast: the minimum boundary of the synchronization range, duration of evolution synchronization at the minimum boundary, Initial respiratory rate, Initial heart rate, age, height, weight, gender, menstrual cycle phase (only for women), diastolic and systolic blood pressure values. Linear and quadratic regression models, and neural network techniques - multilayer perceptron and radial basis function network have been analyzed. Neural network regression has shown the best accuracy: the value of synchronization range of cardiac and respiratory rhythms value can be forecast by these factors with the relative error of 20-30%, the probability will be grow up to level of 80-90%.

The article gives an overview of current legislative and normative-legal acts regulating the relations in the field of the circulation of the medical devices, reporting on the operating procedures and efficiency of the territorial body of the Federal service for health care supervision in carrying out the inspection and enforcement activities in relation to the subjects of the circulation of medical devices; gives a classification of key violations revealed in this field of operation; provides the analysis of the administrative practice regarding the violations of the rules regulating the circulation of the medical devices for 2014.

Sperm parametrs have been studied at 280 patients with chronic prostatitis and 50 somatically healthy persons of the Astrakhan region. Among patients with chronic prostatitis allocated to 2 groups of patients: infertile men (140 people) and fertile men (140 people). Significant differences in the quantity and quality of sperm were found in infertile men compared with a group of fertile men of the Astrakhan region. So, in infertile men there was a decrease in sperm volume, number active motile spermatozoon and their speed. In addition, in the group of infertile men there was an increase in the viscosity of sperm, number of immobile spermatozoon, the number of abnormal forms and dead spermatozoon.

This article presents the results of the study of bone tissue in patients with gastrointestinal diseases. Conducted osteodensimetric study revealed a high prevalence of lower BMD in different areas of the skeleton of these patients. Osteoporosis and osteopenia in patients met more frequently than in the control group. Also showed a significant decrease in the content of vitamin D in blood serum, in comparison with the control group. Identified some factors in the development of osteopenic syndrome in patients with gastrointestinal diseases.

To study the experimental system cardiopatic amyloidosis authors were first obtained by the model in aged rats that allows us to study the etiology and pathogenesis of this disease, and to develop methods of prevention and treatment. Comparative analysis of functional and morphological changes led to the conclusion that in order to further study cardiopatic amyloidosis is advisable to apply a technique with the addition of homogenate of rat myocardium, as in this case, alterative changes in the heart are most pronounced, with minimal changes in other organs and tissues.

The purpose of this study was to analyze the short-term and 1-year long-term results of the treatment including radical surgery and intraoperative radiotherapy (IORT) in patients with primary (PRC) and recurrent rectal cancer (RRC). We retrospectively reviewed 68 patients (pts.) treated with the Intrabeam Photon Radiosurgery System (PRS) following definitive resection of a locally advanced PRC or RRC. Gender distribution was 41 male and 27 female aged from 33 to 82 years (median 64.5). Stage II primary rectal cancer (PRC) was in 50 pts., stage III in 18 pts. RRC was found in 9 pts median follow-up after IORT was 9,6 months. Overall survival and disease free survival rate calculated using Kaplan-Meier analysis. A dose of 5.07Gy was prescribed to a depth of 1 cm (surface dose range was 9.4-17.0, median: 14.8 Gy). Median duration of IORT was 31.9 minutes (range: 15-36). Spheric applicators of 5 cm in diameter used in 40 cases and 4.5 cm - in 5 pts. No intraoperative or postoperative complications were attributed to IORT. Median discharge time after surgery was 17.7 days (range: 9-25). The 1-year overall survival rate was 90,1% (S.E.=4,9). The 1-year local recurrence free survival rate was 89,5% (S.E.=7,1). The 1-year distant metastasis free survival was 88,6% (S.E.=6,5). No cases of hydronephrosis or ureter fibrosis after IORT were documented. Fist experience suggests that Intrabeam PRS appears to be a safe technique for delivering IORT in rectal cancer patients. IORT with PRS marginally increased operative time, and did not appear to prolong hospitalization.

Explored the outer diameter, the angle of divergence, the strength and deformability of the superior cerebellar artery, anterior inferior cerebellar artery and posterior inferior cerebellar artery in adults aged 20-74 years. Study material - 179 samples cerebellar artery obtained at autopsy of adults and 24 arterial drug complexes «arterial circle - cerebral arteries». Methods: traditional anatomical (preparation, microscopy) and experiments on uniaxial longitudinal stretching. It was found that the superior cerebellar artery characterized by the largest outer diameter, angle of divergence, the greatest strength and elongation. Lower front and posterior inferior cerebellar artery do not have significant differences in the studied parameters. It is noted that the lower front cerebellar artery originate from the bottom third of the basilar artery is 1.5 times more than that of the middle third.

Retrospective analysis of elderly and aged patients, data whose anemic syndrome was revealed for the first time in examination and treatment of cardiovascular, nerwous, respiration systems and alimentary tract. Sideropenic anemia stands prevailing being conditioned by hyposiderosis in this group of patients were misrecognized as demonstration of other diseases connected with old age.

We've investigate ultrastructural manifestations of cryoapplicator made from a porous and permeable titan nikelid post-traumatic influence on ciliary body tissues in a rabbit's eye wall. During the experiment on 25 adult rabbits 3, 7, 14 and 30 days after local cryoinfluence eye wall fragments taken from experimental and control animals passed the corresponding procedures for electron microscopy. Already received factogrammes primary viewing convinces in specificity of cryoinfluence effect and structural stromal and a ciliary body elements' remodeling. Thus pinpoint morphological analysis of perinecrotic and remote zones of a stroma and ciliary body cryoapplication testifies more expressive their structural integrity, in comparison with usual mechanical damage consequences by the end of the first supervision week. In a peritraumatic wound zone ultrastructural manifestations of all the myoid and fibrous ciliary body elements intracellular regeneration and reorganization, fibroblasts to miofibroblasts transdifferentiation are stated along with signs of its scarring on the 2-nd and 3-rd weeks of experiment.

The pathology of the organs of the female genitalia, including benign tumors, has a significant impact on the reproductive health of the population. According of the Russian Federation state policy to overcome demographic crisis, the issues of organization of medical aid to women require special attention. The present article is devoted to the rehabilitation and sanatorium treatment as one of the stages of rendering of medical aid to patients with benign tumors of the female genital sphere.

We investigated the intensity of barium sulfate stimulated luminol-dependent chemiluminescence (SLCHL) blood after pre-incubation of blood samples with nonsteroidal anti-inflammatory drugs (NSAIDs), food dye tartrazine in healthy donors and patients with intolerance to NSAIDS, tarirezine with different clinical manifestations. In patients with bronchial manifestations of intolerance to NSAIDS, tarirezine degree of suppression of SLCHL blood increases with the age of the intolerance. Only patients with skin manifestations of intolerance to NSAIDS (urticaria/angioedema) the degree of suppression of SLCHL blood degrades with the age of the intolerance of these agents.

Dramatically changed for the last decades. If is commonly known that clinical manifestations of Parkinsons disease are diverse and consist of autonomic, sensory and neuro-psychiatric disorders. Now days this spectrum of non motional manifestations is considered as a predictor of Parkinsons disease, which show ap 10-20 years earlier than motional symptoms appear.

They researched endothelioprotective and cardioprotective activity of arginase II selective inhibitor (substance code ZB49-0010C) in model of L-NAME-induced deficit of nitric oxide. The results of studies of arginase II selective inhibitor (substance code ZB49-0010C) show the presence dose-dependent endothelioprotective and cardioprotective activity, the severity of which sincreases with increasing dose.

In the literature already described cases of metastasis to the dura (dura) of various cancers. In our observation, the patient was 43 years metastasis of lung cancer (MRI) faked a meningioma of the lateral surface of the Tentorium of cerebellum with compression mediobasal divisions of the right temporal lobe. The patient was operated, histological studies metastasis of papillary adenocarcinoma of the lung in the dura of the tentorium of cerebellum with areas of tumor invasion into the dura. Conclusions on a fairly frequent asymptomatic course of primary tumors, with the manifestation of their brain metastases. The patients with known brain tumors are subject to mandatory search of the primary tumor to exclude metastatic brain lesions and timely initiation of adequate comprehensive treatment.

In recent years, the classification of Cushing complements the cyclic form of Cushing's disease (BIC), the cause of which in most cases is a pituitary tumor - kortikotropinomy. Some patients with cyclic form BIC clinical signs may be unstable or absent, «accidentally» revealed by laboratory study of high levels of cortisol [1]. Set out below shows the history of the patient is rarely found form cyclic Cushing girl 18 years.

The substance SS-68 relaxes smooth muscles cells of tracheal rings of guinea pig in vitro. Such effect is selective for β₂-adrenergic receptors, and type of this influence depends on method of stimulation on insulated trachea. The duration of effect substance SS-68 is not so long (about 15 min for toning after this exposure in concentration 10^-7 M or about 60 min after maximum concentration in compare to super selective β₂-adrenomimetic substance indacaterol maleate (the tonus of tracheal rings after washing away the substance SS-68 was not resorted. An amplitude of relaxation smooth-muscle cells on influence of the substance SS-68 in concentration 10^-7 M is about 47% of the amplitude of relaxation witch has been maded by indacaterol maleate.