Violations of the cell cycle have their own characteristics in the skin lesions. The greatest attention is paid to the research of cancers, whereas benign tumors of the skin insufficiently studied. The article presents data on the characteristics of protein expression of cyclin dependent kinase inhibitor p16, p27, and their role in the cell cycle and oncogenesis.

In experimental periodontitis in rats benzofurokain alongside the traditional drug therapy stimulates angiogenesis thus increasing the vascularization of the regenerate. It also manifests more pronounced ability to lamina propria gums organotypic tissue regeneration in combination with the relief of alterative manifestations in the epithelium. Traditional drug therapy without benzofurokain leads to the development mainly sclerotic changes in the gums without normalization of morphofunctional state of its epithelium.

The work offers a view on the results obtained from a study involving 358 patients of both sexes in the first period of their adulthood who had physiological occlusion of permanent teeth and mesognathic dental arches. In case of those with mesognathic normodontia the angles of vestibular-lingual inclination matched the standard torque braces. Cases of mesognathic macrodontia revealed protrusion of the front teeth while the torque value approached a level that could be described as high. Patients with mesognathic microdontia had their angles of vestibular-lingual inclination close to low torque braces. The angulation angles in cases with mesognathic shape of dental arches revealed virtually no dependence on the size of the permanent teeth, whereas the difference in these indicators was not significant.

The work evaluated the influence of 3-(2,2,2-trimethylhydrazinium) propionate per square necrotic myocardium of the left ventricle and the level troponina I serum during acute coronary occlusion (60 minutes) followed by reperfusion (90 min) in anesthetized rabbits. It is shown that distant and pharmacological preconditioning 3 (2,2,2-trimethylhydrazinium) propionate reduce nekrooza zone 3 and 1.5 times, respectively. Found participation ATP dependent potassium channels (KATF channels) of endothelial and inducible NO-synthase in the implementation of the cytoprotective effect of distant preconditioning and 3-(2,2,2-trimethylhydrazinium) propionate, indicating that the implementation of the mechanism of pharmacological preconditioning in his kardioprotektvnom action.

Over the years, coronary heart disease remains one of the most urgent problems of medicine in the Republic of North Ossetia - Alania. This is associated with high mortality, difficult diagnosis and prevention of this disease. The study involved 859 women residing in the territory of the republic: 475 - urban settlements and 384 - rural-type settlement between the ages of 20-74 years. The study examined the major controllable risk factors coronary heart disease (hypertension, lack of exercise, emotional stress, smoking, alcohol consumption), their prevalence in some areas of the country. The objectives of this research was to identify and depending on the prevalence of the studied risk factors of age and type of settlement. The results show that the frequency of the studied risk factors is higher among women living in urban areas, whereas the percentage of such risk factors as smoking and alcohol consumption currently remains low throughout the region. The most common among the women surveyed hypertension and psycho-emotional voltage, the percentage increases with age.

Using of the combined use of non-selective inhibitor of arginase L-norvaline with simvastatin, atorvastatin, rosuvastatin and rosuvastatin nanopartikulirovanny on background modeling endotoxin-induced disease, the introduction of strain 603 Staphylococcusaureus shows ekdotelio- and cardioprotective effects, manifested in preventing the proliferation of coefficient of endothelial dysfunction (CED), adrenoreactivity, maintaining myocardial reserve and normalization values of biochemical markers (Total NO, Expression of eNOS, C-reactive protein, IL-6, TNF). Thus, combination therapy found no additive effect of drugs.

The observation of 40 patients with discirculatory encephalopathy Ist and IIed stage arising from Hypertensive disease and atherosclerosis. The Ist group - main, patients who received standard therapy in combination with mexiprim. The IIed group - control, patients who received only standard therapy. Evaluated dynamics of clinical manifestation, cognitive function and level of anxiety in the investigated groups after 14 and 28 days. Noted the high efficiency of mexiprim in treatment of clinical manifestation chronic brain ischemia, in comparison with standart therapy.

The work offers a view on the results obtained from a study involving 253 patients of both sexes in the first period of their adulthood who had physiological occlusion of permanent teeth and dolichognathic (i. e. elongated in the sagittal direction) dental arches. It was found that in patients with dolichognathic normodontia as well as macrodontia the angles of vestibular-lingual inclination matched high torque braces. Patients with dolichognathic microdontia had their angles of vestibular-lingual inclination close to standard torque braces. The angulation angles in cases with dolichognathic shape of dental arches revealed virtually no dependence on the size of the permanent teeth, whereas the difference in these indicators was not statistically significant.

Biochemical investigations were performed in 20 patients with fractures of shins and thighs. The patients' age range was between 18 and 50 years. The main method of treatment was skeletal stretching. It required long time limitation of movements. Blood was drawn out on the 7th, 14th, 21st, 28th, and 35th days after traumas. Indicators of enzyme, carbohydrate, purine and lipid metabolism were studied in blood plasma. Direction of metabolic changes depended on the period of immobilization. The findings may be recommended for control of influence of restrictions of movements on posttraumatic processes and should be taken into consideration in administration of complex therapy for the above patients.

The efficacy of cardiotonic drugs on the energy supply system and bioenergetic processes in failing myocardium under severe form heart failure (HF) coupled with systemic inflammatory response syndrom, has been studied in the randomized, controlled trial. It has been shown, that treatment with cardioprotector (NAD- and cardiac glycoside-containing) drug Adenocin® unlike inhibitors of phosphodiesterase, amrinone and levosimendan, abolished the progression of bioenergetics failure and mitochondrial remodeling. Adenocin® occurs restoration of level of redox-potential NAD/NADH and cessates the release of cytochrome C from the mitochondries of cardiomyocyte. HF increased the content of ATP and creatinphosphate in left and right ventricle of myocardium, and restored the level of redox-potential NAD/NADH and cytochrome in mitochondria of cardiomyocytes, that leads in the basis of sharply decrease of ATP and creatinphosphate in myocardium, switch the lactate/pyruvate ratio to the increase of pyruvate (aerobic glycolysis). The linear positive correlation between redox-potential NAD/NADH in ventricular myocardium and blood and negative between level of cytochrome C in myocardium and blood has been shown.

A clinical and radiological study to assess the standard of care for the provision of endodontic tooth periodontal disease. A total of 104 people (85 men and 19 women) aged 18 to 55 years who underwent endodontic treatment of teeth on the various forms of periodontitis. It is found that the standard endodontic and periodontal single rooted teeth multirooted performed respectively in the formation of tooth cavities access to 86.67% and 87.64% of cases; forming the mouth of the root canal - to 80.0% and 83.9% of cases; measuring the working length - in 80.0% and 78.65% of the cases; root formation channel (s) of the tooth - at 86.67% and 84.27% of cases; homogeneity and its (their) obturation filling material is provided in 80.0% and 89.89% of cases. Satisfactory root canal filling servicemen to complete endodontic treatment of periodontitis single rooted, two or three teeth of the root is determined, respectively, 73.33%, 69.23 and 66.67% of cases.

The incidence among soldiers performing military service, higher compared to the civilian population and soldiers performing military service under the contract. Out of the total incidence of more than 50% are respiratory diseases. A high incidence of respiratory diseases can result in the disruption of service and combat missions. There is a high incidence among soldiers of the new replenishment. It is advisable to carry out individual selection in the military to determine the risk of respiratory disease by the method of pulse oximetry. Perhaps the use of pulse oximetry for selection in the special purpose units.

We have conducted the questionnaire survey of 200 patients with the final diagnosis of acute myocardial infarction. The age of patients ranged from 32 to 65 years, the average age was 50.4±1,4 years old. All the respondents had been living in Chelyabinsk and nearby towns. They have answered some questions relating to the the risk of developing atherosclerosis. The records indicated a high prevalence of chronic stress (72%), hypertension (67.5%), overweight (55%), smoking (49%), high cholesterol (42,5%). Less frequently: physical inactivity (20,5%), hyperglycemia (18.5%), poor nutrition (16,5%). Only 26% of the respondents associated the development of the disease with unhealthy lifestyle. Able-bodied citizens don't have enough information about risk factors of developing atherosclerosis and other diseases of the circulatory system. This fact should be taken into account by health care system (it is necessary to develop the preventive measures).

In 40 patients with newly diagnosed colorectal cancer identify circulating tumor cells the Veridex CellSearch system. In the tissue of the tumor was determined by the presence of KRAS mutations for Real-Time qPCR technique. Was found a connection of an elevated number of CTCS in the venous blood with the presence of tumor mutations in the KRAS gene. In patients with high levels of CTCS and the presence of mutations, earlier developed distant metastases.

C-terminal telopeptide of type-I collagen level was studied in 112 chronic heart failure (CHF) patients and in 30 patients without heart failure. As a result, in CHF patients with atrial fibrillation compared to patients with sinus rhythm increase of C-terminal telopeptide of type-I collagen level was revealed. Increase of C-terminal telopeptide of type-I collagen level was also revealed in CHF patients with postinfarction cardiosclerosis compared to patients with no myocardial infarctions history; it reflects the association of maladaptive remodeling of the myocardium in postinfarction cardiosclerosis with intensification of extracellular matrix disorganization and disintegration of interstitial collagen processes.

In the article on the basis of sociological research examines youth values in relation to their body and health. The reasons for changes in your own body linked to a desire to not come from peer groups, look attractive for the opposite sex, art.

Objective - assessment of endogenous intoxication degree in patients with malignant and benign brain tumors after intraoperative photodynamic therapy. It has been established that the identified changes in the indices of endogenous intoxication reflect the degree of malignancy of brain tumors. Surgical intervention combined with intraoperative photodynamic therapy can be a powerful destructive factor that is reflected in the increase in the endotoxemia degree. To increase the effectiveness of treatment of patients with brain tumors additional activities to arrest the endogenous intoxication in the early postoperative period are required.

35 women (middle age 51±2.8 years) with slight atrophy of vaginal tissue confirmed by hystomorphologic analysis were investigated. Pathogeneticaly important metabolic criteria of tissues and peripheral blood erythrocytes sensitive to hypoxia were chosen in the purpose of improve efficacy of early diagnostics of atrophic colpitis. Concentration of 2.3-BPG, lactate and pyruvate was higher in erythrocytes of all women in clinical group in relation to group of compare. Inhibition of respiratory chain enzymes activity: succinatedehydrogenase and cytochromeoxydase was registered in vaginal tissue of women in clinical group taking intra operationally. Our results testify about changes in metabolism of tissue and erythrocytes that can be early markers of atrophy formation. The results of our investigation gave us the possibility to create the new method of hypoxia diagnostic as predictor of tissue atrophic changes.

To assess the incidence of cervical lesions according to cytology (oncocytology) and the study of their relationship with the identification of human papillomavirus. High risk the analysis cytological findings traditional cervical smear in combination with liquid-based cytology and human papillomavirus testing among 800 women. It is shown that infection with the human papillomavirus. High risk is prevalent in young women, but the severity of cervical lesions increases after 30 years.

The article is devoted to study of efficacy of surgical methods of treatment of secondary hyperparathyroidism which is refractory to therapy using active metabolites of D vitamin in patients with stage V chronic renal disease receiving treatment with program hemodialysis. In some cases the surgical treatment of the advanced stage of secondary hyperparathyroidism, PTH reduction was not observed, but patients reported clearly the disappearance or reduction of the pain in the bones and joints and also the normalization of calcium phosphorus metabolism. We are adhere to surgical treatment method consisting in removing of enlarged parathyroid glands with further conservative therapy that helps to avoid postoperative hypoparathyroidism, normalize the levels of parathyroid hormone and improves the quality of life of patients.

The role of gene polymorphism A2 receptors platelet glycoprotein IIb/IIIa in the development of systemic endothelial dysfunction in pregnant women. Patients A2 polymorphism observed increase in markers of endothelial dysfunction, increased production of pro-inflammatory cytokines, increased free-radical reactions, decreased antioxidant activity, especially in the group of women with the polymorphism P1^A2/P1^A2.

Clinical method were used to examine 200 young men of draft age having autoagresstive actions in the anamnesis. It was revealed a complex clinical-psychopathological and social factors that influence the likelihood of autoagressive behavior.

This study examines the characteristics ventricular-arterial interaction and the efficiency of left ventricle in patients with ischemic cardiomyopathy. We examined 120 male patients (mean age 57,4±1,9 years) with ischemic cardiomyopathy. The comparison group consisted of 80 patients matched for gender and age (mean age of 58,1±1,7 years) with myocardial infarction in anamnesis and preserved systolic left ventricular function. Revealed that in patients with coronary heart disease is a disturbance of the interaction between left ventricle and arterial bed. In this case, patients with ischemic cardiomyopathy there is a distinct lack of reserve as left ventricular and arterial elastances. In this condition the trends of the external work of the left ventricle, the potential energy and the «pressure - volume» is increased and the mechanical efficiency of the left ventricle decreases.

Evaluate the effectiveness of methods used by the temporary closure of the abdomen and bring our original method of closure. In the departments of surgery Simferopol we have developed an original method of the temporary closure of the abdominal cavity with the use of negative pressure. The key points are: 1. Shelter transparent perforated plastic film of the abdominal cavity after the main phase of the operation. This film completely separates the parietal peritoneum of the anterior abdominal wall from the internal organs, preventing the formation of adhesions adhesions. The distance between the defects in the film is about 5 cm, 0.5 cm defect dimensions; 2. The polyethylene film is laid on top of a sponge in the shape of an octopus. «Tentacles» reach octopus side channels, allowing to drain the pathological exudate is localized in the depth of the abdominal cavity; 3. Next, fit the other a sponge in the form of performing laparotomy wound edges without tension. In this sponge have channels for drainage, connected to the system of negative pressure; 4. A foam sponge laparotomic wounds and skin adhesive film is glued to seal the abdominal cavity. This design is advantageous because by its internal organs, discharge from the abdominal cavity measurable, implemented gradually medial traction edges of the anterior abdominal wall, the patient remains dry and clean, and requires minimal nursing care. The above procedure was used in 5 patients diagnosed with secondary peritonitis. The severity of the condition for admission system APACHE II score was 18-24. Final relaparotomy completed stratified tissue suturing. All the patients survived. A method of temporary closure of the abdominal cavity (modified VAC-system) has been successfully put into practice. Further research is needed in order to obtain reliable results of the study and improvement of methods.

The article describes the use of a da Vinci-assisted (DV) gynecological surgery. DV is the biggest technological development of the recent decades. Currently, over 4000 robotic surgical systems in 54 developed countries and 25 robotic surgical systems in Russia have been used successfully. The type of robot-аssisted gynecological interventions is wide: from uterus-sparing surgery to radical hysterectomy.

We have studied indicators of oxidative stress (carbonyl derivatives and TBA-active products) and antioxidant protection (activity of superoxide dismutase) at infertile (140) and fertile (140) patients with chronic prostatitis on a background of sexually transmitted infections (STIs). The increase in activity of lipid peroxidation was revealed in the serum of infertile patients with chronic prostatitis, statistically significantly dependent on STI. Installed, the presence of mixed infection in infertile patients with chronic prostatitis is the most adverse factor that triggers the development of oxidative stress and contributing to its persistence.

The aim of the study was to increase the effectiveness of prevention of dysfunctional states of the temporomandibular joint (TMJ) in elderly and senile age by developing and implementing new approaches to health education as part of the creation and implementation of the program «Prevention of diseases of the temporomandibular joint in elderly and senile». To achieve the objectives were examined 86 patients from 60 to 83 years: 25 patients with symptoms of diseases TMJ found as a result of uptake with complaints of difficulty in chewing, aesthetic dissatisfaction, and 61 patients who were sent for consultation gnathology doctors another profile under the program "Prevention of diseases of the temporomandibular joint in elderly and senile."

The results of morphological changes in temporomandibular joint (TMJ) with 30 experimental animals in the process of modeling fibrous ankylosis are given in the article. The analysis of the results obtained has shown the positive impact of transkranial electric stimulation (TES-therapy) which reduced the destructive processes in bone tissue of mandibular head and mandibular fossa thus accelerating the process of their restructuring and the promotion of osteogenesis process compared to the fabrics of TMJ with experimental animals to whom the TES-therapy has not been applied.

The metabolic characteristics of blood of animals following subchronic exposure of gaseous mixtures containing singlet oxygen were investigated. The experiment was carried out on Wistar rats. In the blood the concentration of glucose, lactate, the activity of catalase, aldehyde dehydrogenase, lactate dehydrogenase were determined after 30 and 60 days after externally-inhalation. It is shown that prolonged use for 30 days gas mixture containing singlet oxygen, increases the detoxification function and antioxidant reserve of erythrocytes, decreases the concentration of glucose in blood, leading to reduction of the coefficient of energy reaction balance and the accumulation of lactate in erythrocytes. Long-term results (60 day) of externally-inhalation of a gas mixture containing singlet oxygen, reveal a violation of energy metabolism blood normalizing the specific activity of aldehyde dehydrogenase and increasing the catalase of erythrocytes, increasing concentration of glucose in blood.

Experimental estimation of pro- and anti-inflammatory cytokines balance in aqueous eye chamber liquid in case of intraocular implantation of drainage material made of nickelid titanium and intraocular application of a solid retention suture TH-10. Investigation of aqueous eye chamber liquid sampled on the 3rd, 7th and 30th days and in 3 months and in 1,5 year after intraocular implantation with nickelid titanium TH-10 used as a drainage and fixative device have been studied during experiment with 26 mature rabbits. The control group consisted of 6 intact rabbits as well as of 5 rabbits for whom perforating hypotensive surgical interference without drainage device implantation have been administered in various periods of monitoring. The opposite nature of cytokines balance changes and proportion of its pro- and anti-inflammatory element in the dynamics after intraocular implantation of a nickelid titanium and solid suture TH-10, which shows positive anti-inflammatory influence of materials made of nickelid titanium basis, that is manifested in significant reduction of anti-inflammatory component of cytokines balance and shows its maximum in the utmost tardy periods of monitoring, as well in clinically unresponsive postoperative course with animals of experimental group compared to the group of comparison.

In this paper we present the results of pathomorphological studies of autopsy specimens, especially the morphology, frequency and extent of visceral manifestations of amyloidosis in different climatic densely populated sparsely populated plains and foothillmountain areans of the Republic of North Ossetia - Alania in terms of their comparative statistical and climatic characteristics. The results of the study can serve as a reliable index reflecting the dynamics of frequency and severity of various organ and systemic forms of amyloidosis in areas of the republic with different climatic regimen. The obtained data can serve as the basis for the development of new approaches for further study of amyloidosis, its prevention and pathogenetic therapy.

To evaluate the results of surgical treatment of patients with diffuse-generalized form of hypertrophic cardiomyopathy by performing extended myectomy ventricular septal longitudinal parietal resection of the hypertrophied papillary muscles and universal mitral valve replacement. We have operated 18 patients (10 men and 8 women) with diffuse-generalized form of hypertrophic cardiomyopathy HCM. The average age of the patients was 48 ± 10,9 years. Hospital mortality was 0%. At 1 year after surgery according echocardiogram thickness of interventricular septum decreased from 1,9 ± 0,3 cm to 1,5 ± 0,2 cm, the pressure gradient in the left ventricular outflow tract decreased from 75,9 ± 5,6 mm. Hg up to 3,2 mm Hg ± 20.4, the size of the left atrium decreased from 4,5 ± 0,4 to 4,2 ± 0,3 cm. The functional class decreased from III to I-II NYHA. In the late postoperative period (2 years), 1 patient died. Conclusion: The results indicate that our proposed method of surgical treatment of diffuse - a generalized form of HCM is an effective procedure that gives good functional results.

To evaluate the activity of microbicidal system of neutrophylic granulocytes while stimulated by different doses of electrolytic solution of silver (ESS) to increase the absorbing and digesting potential of microbic bodies in phogocytosis. In the research there were used 44 male rabbits of equal weight. After obtaining check index of phagocytosis the investigated doses of ESS were given intravenously with saccharose. In 30, 60 and 120 minutes blood samples were taken to investigate the core parameters of phagocytic activity of neutrophyles (activity of microbicidal system of neutrophylic granulocytes, absorbing and digesting potential of microbic bodies). As a consequence of introvenous input of ESS the number of active neutrophyles increased, as well as the amount of bacterias absorbed and digested. The most effective dose was 0,025 mg of silver per kg. Small amounts of ESS efficiently stimulate the microbicidal system of neutrophylic granulocytes, which is shown by the increase of phagocytic activity.

A prospective analysis of a multiple uterine myoma patient's favorable pregnancy and childbirth has been carried out, as well as an analysis of this patient's second six-month pregnancy and its outcome after delivering by cesarean section and removing myoma nodes. After successful second delivery by cesarean section, the woman was discharged home with a baby in a satisfactory condition. Reproductive function is preserved.

This article presents results of laparoscopic hysterectomy among obese patients. Technical aspects, complications rate, operative time, length of hospital stay in relation to BMI were analyzed. Also we present results of international surgical experience of extremely overweight cases.